Role of μ-calpain in proteolytic cleavage of brain l-glutamic acid decarboxylase
نویسندگان
چکیده
منابع مشابه
Calpain Cleavage of Brain Glutamic Acid Decarboxylase 65 Is Pathological and Impairs GABA Neurotransmission
Previously, we have shown that the GABA synthesizing enzyme, L-glutamic acid decarboxylase 65 (GAD65) is cleaved to form its truncated form (tGAD65) which is 2-3 times more active than the full length form (fGAD65). The enzyme responsible for cleavage was later identified as calpain. Calpain is known to cleave its substrates either under a transient physiological stimulus or upon a sustained pa...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2008
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2008.02.033